Everyone is talking about Ketogenic Diets, Artificial Sweeteners, Fast Foods, Sugar, Weight and Appetite Control, Ozempic, The truth is they can all cause or induce persistent insulin resistance.
Because of rising environmental toxins, thousands of food additives, the lack of nutrient density of food grown on depleted soil and the attraction and addiction to fast foods and sugar there is the emerging understanding that Insulin Resistance is the major cause of disease in the 21st Century. It is the key factor in the development of obesity, type 2 diabetes, cardiovascular disease, fatty liver disease especially NALFD, neurodegenerative disease especially Alzheimer’s, and obesity-associated cancers like breast and colon cancer.
A focus on weight loss(5) by utilizing ketogenic diets, intermittent fasting, popular sugar substitutes, appetite control with Ozempic and Semiglutide has come into mainstream marketing and social media.
Recent studies at Yale University of Medicine, Endocrinology show that 10% weight loss and regular exercise can reverse insulin resistance and reduce the risk of most serious diseases. The studies used an 1,200 calorie restricted diet to achieve a 10% weight loss, reverse fat deposition in the liver and reverse Type 2 Diabetes. Outcome of Dr Shulman’s Review of Clinical Trials
To my patients seeking weight loss, to those using a ketogenic diet and especially to those who have struggled with the last 10% of excess weight and to those who tend to regain all their weight back and-
To all those who cannot break the A1C barrier of 5.6 or higher, I can explain an amazing relationship between the sense of taste, the gut and the brain:
I was grappling with certain patients who have significant health challenges, medical diagnoses and major risk factors. In geek terms, how can I explain the need to restore mitochondrial function.
Everyone knows that excess or mindless eating, fast food and sugar addictions have been the result of social and advertising influences and nutrient dense-poor foods. So why are they stuck in a constant health problem battle of weight issues and disease risk?
Why Ketogenesis is popular: How it works Metabolically
Long term benefits of ketogenesis for repair and the maintenance of an ideal weight is a function of the interplay of energy expenditure and weight loss, governed intrinsically by a network of feedback loops controlled by hormones and peptides combined with increasing
One of the best interventions besides metformin is by achieving a specific level of fat burning with a ketogenic diet. See link to GKI, the glucose-ketone-index for details. But read below first.
Sorry to rain on your parade
The consequence of using sugar substitutes: Ingestion of Artificial Sweeteners (AS) will reduce caloric intake from sugars and carbs. However, these zero-calorie sweet substitutes are mistaken as sugar by the brain due to their sweet taste, resulting in insulin release from the pancreas.
Allow me to explain first about Artificial Sweeteners
Within the silos of my mind I woke up realizing that artificial sweeteners can cause insulin resistance.
Diving into the research behind this truth:
Despite the wide variation in day-to-day feeding of different diets and physical activity, body weight remains stable or resets to a previous equilibrium. Body types of quantity and location of fat cells appears to be the result of an epigenetic lottery. Additionally, as a result of socioeconomic pressures, there is a preoccupation with comfort foods especially satisfying the taste for sweets(5).
The sweet taste directly alters gherkin and leptin levels, the major satiety (Gherlins) and master weight control (Leptin) hormones(7). Additionally, gut peptide receptors directly dysregulates the Gut-Hypothalamic Axis. Multiple gut proteins and peptides are involved including GLP-1 and PYY(3).
These peptides are induced by artificial sweeteners and certain drugs, GLP-1 has been the target for profit to cause anorexia, with Ozempic and Semiglutide. Sugar substitutes, like Sucrolose and as old as saccharine and the so-called natural sweeteners, Xylitol, stevia, allulose, Erithritol have moved into the sweets addiction scene.
This problem is perpetuated by the social pressure to seek self-satisfaction. Included in this preoccupation are hard-core illegal drugs, alcohol, pleasure and eating as the underlying message of money-making advertising by sugar lobbyists.(1,2)
Bottom Line
Long term benefits of ketogenesis for repair and the maintenance of an ideal weight is a function of the interplay of energy expenditure and weight loss, governed intrinsically by a network of feedback loops controlled by hormones and peptides indicated by increasing the serum glucose-ketone ratios, the glucose-ketone index.
References:
- Kearns CE, Schmidt LA, Glantz SA. Sugar Industry and Coronary Heart Disease Research: A Historical Analysis of Internal Industry Documents. JAMA Intern Med. 2016 Nov 1;176(11):1680-1685. doi: 10.1001/jamainternmed.2016.5394. Erratum in: JAMA Intern Med. 2016 Nov 1;176(11):1729. doi: 10.1001/jamainternmed.2016.6774. PMID: 27617709; PMCID: PMC5099084.
- NPR.org SEPTEMBER 13, 2016. https://www.npr.org/sections/thetwo-way/2016/09/13/493739074/50-years-ago-sugar-industry-quietly-paid-scientists-to-point-blame-at-fat
- Riediger T, Bothe C, Becskei C, Lutz TA. Peptide YY directly inhibits ghrelin-activated neurons of the arcuate nucleus and reverses fasting-induced c-Fos expression. Neuroendocrinology. 2004;79(6):317-26. doi: 10.1159/000079842. Epub 2004 Jul 15. PMID: 15256809.
- Lund J, Lund C, Morville T, Clemmensen C. The unidentified hormonal defense against weight gain. PLoS Biol. 2020 Feb 25;18(2):e3000629. doi: 10.1371/journal.pbio.3000629. PMID: 32097406; PMCID: PMC7041792.
- Hall KD, Kahan S. Maintenance of Lost Weight and Long-Term Management of Obesity. Med Clin North Am. 2018 Jan;102(1):183-197. doi: 10.1016/j.mcna.2017.08.012. PMID: 29156185; PMCID: PMC5764193.
- Spitzweg C, Hofbauer LC, Landgraf R, Heufelder AE. Molekulare Pathogenese der Adipositas. Physiologische und pathophysiologische Rolle von Leptin [The molecular pathogenesis of obesity. The physiological and pathophysiological role of leptin]. Dtsch Med Wochenschr. 1996 Sep 13;121(37):1134-8. German. doi: 10.1055/s-2008-1043117. PMID: 8925729.
- Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998 Oct 22;395(6704):763-70. doi: 10.1038/27376. PMID: 9796811.
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